Oncolytic Adenoviruses for Cancer Therapy

Many immuno-therapeutic strategies are currently being developed to fight cancer. In this scenario, oncolytic adenoviruses (Onc.Ads) have an interesting role for their peculiar tumor selectivity, safety, and transgene-delivery capability. The major strength of the Onc.Ads is extraordinary immunogenicity that leads a strong T-cell response, which, together with possibility delivery therapeutic transgene, could be more effective than current strategies. review, we travel in adenovirus (Ads) world, focusing on variety can enhance antitumoral efficacy, passing through microenvironment modulation. Onc.Ads-based constitute additional weapons against cancer appear potentiate conventional immune checkpoint inhibitors (ICIs)-based therapies leading promising scenario.